Genetic Characterization of a Novel HIV-1 CRF07_BC/CRF55_01B Recombinant Form Identified in Jiangmen, China
| Autor: | Min Han, Donghe Zhang, Nancai Zheng, Guifang Hu, Lihua Wang, Xin Guan, Zhiju Li, Shixing Tang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine China Genotype Immunology Human immunodeficiency virus (HIV) HIV Infections Genome Viral Biology medicine.disease_cause law.invention 03 medical and health sciences 0302 clinical medicine law Virology Drug Resistance Viral medicine Humans 030212 general & internal medicine Phylogeny Recombination Genetic virus diseases Sequence Analysis DNA 030104 developmental biology Infectious Diseases Mutation Mutation (genetic algorithm) HIV-1 Recombinant DNA RNA Viral |
| Zdroj: | AIDS Research and Human Retroviruses. 36:134-137 |
| ISSN: | 1931-8405 0889-2229 |
| DOI: | 10.1089/aid.2019.0141 |
| Popis: | New recombinant variants are a predominant challenge for preventing the spread of the HIV-1 epidemic. In this study, we confirmed a novel HIV-1 CRF07_BC/CRF55_01B recombinant form for the first time, which was isolated from a male patient in Jiangmen, China. The genomic sequence of the variant with four CRF55_01B segments inserted into the CRF07_BC backbone is 8,510 bp in length, extending from nucleotides 669 to 9,293 according to the HXB2 genome. Specifically, the recombinant strain contains site mutations associated with drug resistance. |
| Databáze: | OpenAIRE |
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