A retrospective study of canine D-dimer concentrations measured using an immunometric Point-of-Care test

Autor: E Dewhurst, SM Cue, EM Crawford, Kostas Papasouliotis
Rok vydání: 2008
Předmět:
Zdroj: Journal of Small Animal Practice. 49:344-348
ISSN: 1748-5827
0022-4510
DOI: 10.1111/j.1748-5827.2008.00583.x
Popis: Objectives: To measure the D-dimer concentrations in both healthy dogs and dogs with and without evidence of thromboembolic disease/disseminated intravascular coagulation using a “Point-of-Care” test. Methods: Sixty-seven clinical cases and 26 healthy dogs were included in this retrospective study. D-dimer was measured using the NycoCard D-dimer test. Clinical conditions were categorised based on clinical findings, laboratory results, imaging, cytology, histopathology, necropsy or a combination of these tests. Results: There were no dogs for which the NycoCard D-dimer test did not produce a result. The D-dimer range in clinically healthy dogs was 0·1 to 0·5 mg/l (median 0·2 mg/l). In eight of nine cases with thromboembolic disease/disseminated intravascular coagulation and 43 of 58 of the cases without thromboembolic disease/disseminated intravascular coagulation , the D-dimer concentrations were greater than those of healthy dogs. Clinical Significance: The NycoCard D-dimer test card required no specialised equipment and could therefore facilitate rapid screening for thromboembolic disease/disseminated intravascular coagulation in first opinion practice. Elevations in D-dimer concentration can be found in a number of clinical conditions apart from thromboembolic disease/disseminated intravascular coagulation and should not therefore be used as the sole basis of diagnosis. D-dimer may be considered a good screening test for thromboembolic disease/disseminated intravascular coagulation as only one case with histopathological evidence of thromboembolic disease/disseminated intravascular coagulation had a D-dimer concentration in the range seen in healthy dogs.
Databáze: OpenAIRE