Exhaled Nitric Oxide Fraction as an Add-On to ACQ-7 for Not Well Controlled Asthma Detection
| Autor: | Plaza, Vicente, Ramos-Barbón, David, Muñoz, Ana María, Fortuna Gutiérrez, Ana Mª, Crespo Lessmann, Astrid, Murio, Cristina, Palomino, Rosa, Universitat Autònoma de Barcelona |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Spirometry medicine.medical_specialty Time Factors lcsh:Medicine Nitric Oxide Sensitivity and Specificity Pulmonary function testing Maintenance therapy Surveys and Questionnaires Asthma control Internal medicine Outcome Assessment Health Care Humans Medicine Anti-Asthmatic Agents Prospective Studies lcsh:Science Asthma Multidisciplinary medicine.diagnostic_test business.industry lcsh:R Airway inflammation Reproducibility of Results Middle Aged respiratory system medicine.disease Respiratory Function Tests respiratory tract diseases Breath Tests Exhalation Exhaled nitric oxide Physical therapy Sputum lcsh:Q Female medicine.symptom business Research Article Follow-Up Studies |
| Zdroj: | PLoS One r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname PLoS ONE Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona PLoS ONE, Vol 8, Iss 10, p e77085 (2013) |
| ISSN: | 1932-6203 |
| Popis: | Background: The measurement of fractional nitric oxide concentration in exhaled breath (FeNO), a noninvasive indicator of airway inflammation, remains controversial as a tool to assess asthma control. Guidelines currently limit asthma control assessment to symptom and spirometry based appraisals such as the Asthma Control Questionnaire-7 (ACQ-7). We aimed at determining whether adding FeNO to ACQ-7 improves current asthma clinical control assessment, through enhanced detection of not well controlled asthma. Methods: Asthmatic subjects, classified as not well controlled as per ACQ-7 on regular clinical practice, were included in a prospective, multicenter fashion, and had their maintenance treatment adjusted on visit 1. On follow-up (visit 2) four weeks later, the subjects were reevaluated as controlled or not well controlled using ACQ-7 versus a combination of FeNO and ACQ-7. Results: Out of 381 subjects enrolled, 225 (59.1%) had not well controlled asthma on visit 2 as determined by ACQ-7, and 264 (69.3%) as per combined FeNO and ACQ-7. The combination of FeNO to ACQ-7 increased by 14.8% the detection of not well controlled asthma following maintenance therapy adjustment. Conclusions: The addition of FeNO to ACQ-7 increased the detectability of not well controlled asthma upon adjustment of maintenance therapy. Adding a measure of airway inflammation to usual symptom and spirometry based scores increases the efficacy of current asthma clinical control assessment. |
| Databáze: | OpenAIRE |
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