Phthalates in German daycare centers: Occurrence in air and dust and the excretion of their metabolites by children (LUPE 3)
| Autor: | R. Burghardt, L. Fembacher, Thomas Lahrz, Martin Kraft, S. Sievering, S. Dietrich, Wolfgang Völkel, Gabriele Bolte, Ralph Schuster, Hermann Fromme |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Tolerable daily intake endocrine system Dibutyl phthalate Metabolite Population Phthalic Acids Urine Excretion chemistry.chemical_compound Germany Biomonitoring Humans Child education lcsh:Environmental sciences General Environmental Science lcsh:GE1-350 education.field_of_study Chemistry Air Phthalate Infant Dust Child Day Care Centers Child Preschool Environmental chemistry Environmental Pollutants Female Environmental Monitoring |
| Zdroj: | Environment International, Vol 61, Iss, Pp 64-72 (2013) |
| ISSN: | 0160-4120 |
| Popis: | Phthalates have been used for decades in large quantities, leading to the ubiquitous exposure of the population.In an investigation of 63 German daycare centers, indoor air and dust samples were analyzed for the presence of 10 phthalate diesters. Moreover, 10 primary and secondary phthalate metabolites were quantified in urine samples from 663 children attending these facilities. In addition, the urine specimens of 150 children were collected after the weekend and before they went to daycare centers.Di-isobutyl phthalate (DiBP), dibutyl phthalate (DnBP), and di-2-ethylhexyl phthalate (DEHP) were found in the indoor air, with median values of 468, 227, and 194 ng/m3, respectively. In the dust, median values of 888 mg/kg for DEHP and 302 mg/kg for di-isononyl phthalate (DiNP) were observed. DnBP and DiBP were together responsible for 55% of the total phthalate concentration in the indoor air, whereas DEHP and DiNP were responsible for 70% and 24% of the total phthalate concentration in the dust.Median concentrations in the urine specimens were 44.7 μg/l for the DiBP monoester, 32.4 μg/l for the DnBP monoester, and 16.5 μg/l and 17.9 μg/l for the two secondary DEHP metabolites. For some phthalates, we observed significant correlations between their concentrations in the indoor air and dust and their corresponding metabolites in the urine specimens using bivariate analyses. In multivariate analyses, the concentrations in dust were not associated with urinary metabolite excretion after controlling for the concentrations in the indoor air.The total daily “high” intake levels based on the 95th percentiles calculated from the biomonitoring data were 14.1 μg/kg b.w. for DiNP and 11.9 μg/kg b.w. for DEHP. Compared with tolerable daily intake (TDI) values, our “high” intake was 62% of the TDI value for DiBP, 49% for DnBP, 24% for DEHP, and 9% for DiNP. For DiBP, the total daily intake exceeded the TDI value for 2.4% of the individuals. Using a cumulative risk-assessment approach for the sum of DEHP, DnBP, and DiBP, 20% of the children had concentrations exceeding the hazard index of one. Therefore, a further reduction of the phthalate exposure of children is needed. Keywords: Phthalates, DEHP, DnBP, Indoor air, Dust, Urine |
| Databáze: | OpenAIRE |
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