Is combination therapy the next step to overcome resistance and reduce toxicities in melanoma?
| Autor: | John B. A. G. Haanen, Jan H.M. Schellens, C.M. Nijenhuis, Jos H. Beijnen |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Proto-Oncogene Proteins B-raf
Oncology medicine.medical_specialty Indoles Combination therapy Drug resistance Pharmacology Mice Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Animals Humans Neoplasm Combined Modality Therapy Radiology Nuclear Medicine and imaging Progression-free survival Vemurafenib Melanoma Protein Kinase Inhibitors Clinical Trials as Topic Sulfonamides business.industry General Medicine medicine.disease Clinical trial Drug Resistance Neoplasm Mutation business medicine.drug |
| Zdroj: | Cancer Treatment Reviews. 39:305-312 |
| ISSN: | 0305-7372 |
| Popis: | In the last few years, several drugs targeting signalling proteins critical for melanoma entered clinical evaluation. In 2011 vemurafenib (Zelboraf®, F. Hoffman-La Roche Ltd.) was approved for BRAF V600-positive melanoma and showed high overall response rates (48-53%). However recent results from a phase II clinical trial also showed that the median duration of response was 6.7months and median progression free survival was 6.8months with tumour relapse. Resistance to targeted agents is quite common and understanding of the underlying molecular mechanisms might predict response or failure. The knowledge of the mechanisms involved in intrinsic and acquired resistance to mutated BRAF is increasing swiftly. Subsequently the elucidation of these mechanisms resulted in the development of rational combination therapies to overcome toxicity and resistance. These combination therapies will be discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect