Behavioral and Cortical Correlates of Self-Suppression, Anticipation, and Ambivalence in Rat Tickling
| Autor: | Shimpei Ishiyama, Michael Brecht, Lena V. Kaufmann |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male media_common.quotation_subject Biology Somatosensory system General Biochemistry Genetics and Molecular Biology Laughter 03 medical and health sciences 0302 clinical medicine Sensation medicine Microstimulation Animals Rats Long-Evans media_common Tickling Somatosensory Cortex Anticipation Rats Affect 030104 developmental biology Touch Perception Touch Gabazine GABAergic General Agricultural and Biological Sciences Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Current biology : CB. 29(19) |
| ISSN: | 1879-0445 |
| Popis: | The relationship between tickling, sensation, and laughter is complex. Tickling or its mere anticipation makes us laugh, but not when we self-tickle. We previously showed rat somatosensory cortex drives tickling-evoked vocalizations and now investigated self-tickle suppression and tickle anticipation. We recorded somatosensory cortex activity while tickling and touching rats and while rats touched themselves. Allo-touch and tickling evoked somatotopic cortical excitation and vocalizations. Self-touch induced wide-ranging inhibition and vocalization suppression. Self-touch also suppressed vocalizations and cortical responses evoked by allo-touch or cortical microstimulation. We suggest a global-inhibition model of self-tickle suppression, which operates without the classically assumed self versus other distinction. Consistent with this inhibition hypothesis, blocking cortical inhibition with gabazine abolished self-tickle suppression. We studied anticipation in a nose-poke-for-tickling paradigm. Although rats nose poked for tickling, they also showed escaping, freezing, and alarm calls. Such ambivalence ("Nervenkitzel") resembles tickle behaviors in children. We conclude that self-touch-induced GABAergic cortical inhibition prevents self-tickle, whereas anticipatory layer 5 activity drives anticipatory laughter. VIDEO ABSTRACT. |
| Databáze: | OpenAIRE |
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