H pylori: Treatment for the patient only or the whole family?
| Autor: | Orhan Sahin, Omer Bender, Vahit Tunali, Oguz Koc, Yavuz Selim Sari, Didem Can |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Risk medicine.medical_specialty Peptic Ulcer Group ii Adenocarcinoma Environment Gastroenterology law.invention Helicobacter Infections Randomized controlled trial law Stomach Neoplasms Internal medicine mental disorders medicine Odds Ratio Prevalence Humans Prospective Studies Prospective cohort study Family Health biology Helicobacter pylori business.industry General Medicine Odds ratio H pylori infection biology.organism_classification bacterial infections and mycoses Confidence interval Regimen Female business Rapid Communication |
| Zdroj: | World journal of gastroenterology. 14(8) |
| ISSN: | 1007-9327 |
| Popis: | AIM: To compare the effects of treatment of H pylori-infected individuals with the effects of treatment of individuals as well as all H pylori-infected family members. METHODS: H pylori-positive patients with similar demographic specifications were prospectively randomized with respect to treatment, with a triple regimen of either patients and all H pylori-positive family members living together (groupI) or patients only (group II). Nine months after treatment, all patients were assessed for H pylori positivity. RESULTS: There were 70 H pylori-positive patients in each group; patients in groupsIand II lived with 175 and 190 H pylori-positive relatives, respectively. Age, sex and H pylori positivity rate were similar in both groups of relatives. Nine months after 14 d standard triple therapy, H pylori positivity was 7.1% in groupIpatients and 38.6% in group II patients [P < 0.01, OR = 8.61 95% confidence interval (CI): 2.91-22.84]. CONCLUSION: The present results indicate bad environmental hygienic conditions and close intra-familial relationships are important in H pylori contamination. These findings indicate all family members of H pylori-positive individuals should be assessed for H pylori positivity, particularly in developing countries where H pylori prevalence is high; they also suggest patients, their spouses and all H pylori-positive family members of H pylori-positive individuals should be treated for H pylori infection. |
| Databáze: | OpenAIRE |
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