The Plateau of the Action Potential of the Frog Ventricle
| Autor: | W. V. Macfarlane |
|---|---|
| Rok vydání: | 1960 |
| Předmět: |
Heart pharmacology
Cyanides Nitrogen Physiology Stereochemistry Chemistry Heart Ventricles Action Potentials Heart Iodoacetates Plateau (mathematics) Differential effects Nitrophenols medicine.anatomical_structure Ventricle Active Ion Transport Biophysics medicine Cardiology and Cardiovascular Medicine |
| Zdroj: | Circulation Research. 8:47-56 |
| ISSN: | 1524-4571 0009-7330 |
| DOI: | 10.1161/01.res.8.1.47 |
| Popis: | A study was made of the changés produced in action potentials of frog ventricular cells by variation in ion concentrations, by administration of NaN 3 , 2:4 DNP, NaCN, NaIA and N 2 which shortened the potentials. The exposure of the perfused tissue to ionized acridines, barbiturates and desoxyglucose caused a prolongation of the action potentials. These actions as obtained were reversible. The evidence from the time-course and differential effects of inhibitors suggests that an active ion transport, modulated by K o + may be important in maintaining the plateau phase of the action potential. |
| Databáze: | OpenAIRE |
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