pH-responsive and targeted delivery of chrysin via folic acid-functionalized mesoporous silica nanocarrier for breast cancer therapy

Autor: Noyel, Ghosh, Mousumi, Kundu, Sumit, Ghosh, Abhishek, Kumar Das, Samhita, De, Joydeep, Das, Parames C, Sil
Rok vydání: 2023
Předmět:
Zdroj: International Journal of Pharmaceutics. 631:122555
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2022.122555
Popis: Cancer is a disease of global importance. In order to mitigate conventional chemotherapy-related side effects, phytochemicals with inherent anticancer efficacy have been opted. However, the use of nanotechnology is essential to enhance the bioavailability and therapeutic efficacy of these phytochemicals. Herein, we have formulated folic acid conjugated polyacrylic acid capped mesoporous silica nanoparticles (̴ 47.6 nm in diameter) for pH-dependent targeted delivery of chrysin to breast cancer (MCF-7) cells. Chrysin loaded mesoporous silica nanoparticles (Chr- mSiO
Databáze: OpenAIRE
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