A molecular Rosetta Stone to decipher the impact of chromatin features on the repair of Cas9-mediated DNA double-strand breaks
| Autor: | Sophie E. Polo, Pierre Caron, Enrico Pobega |
|---|---|
| Přispěvatelé: | Centre épigénétique et destin cellulaire (EDC (UMR_7216)), Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Double strand
0303 health sciences Cas9 [SDV]Life Sciences [q-bio] Context (language use) Cell Biology Computational biology Biology Chromatin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Dsb repair DECIPHER Molecular Biology 030217 neurology & neurosurgery DNA ComputingMilieux_MISCELLANEOUS 030304 developmental biology |
| Zdroj: | Molecular Cell Molecular Cell, Elsevier, 2021, 81 (10), pp.2059-2060. ⟨10.1016/j.molcel.2021.04.024⟩ |
| ISSN: | 1097-2765 |
| DOI: | 10.1016/j.molcel.2021.04.024⟩ |
| Popis: | Using a barcoded reporter introduced within a thousand different chromatin locations in human cells, (Schep et al., 2021) characterize repair outcomes of Cas9-induced DNA double-strand breaks (DSBs) and the relative use of DSB repair pathways depending on the local chromatin context. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|