Adhesion prevention comparing liquid and solid barriers in the rabbit uterine horn model
| Autor: | Karl H. Treutner, A. P. Oettinger, M. Anurov, Volker Schumpelick, Stefan A. Müller, Hendrik Jörn |
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| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Polyesters medicine.medical_treatment biology.animal_breed Adhesion (medicine) Tissue Adhesions Icodextrin chemistry.chemical_compound Gynecologic Surgical Procedures Postoperative Complications Animal model Hyaluronic acid Animals Medicine Adhesion prevention Hyaluronic Acid Glucans Phospholipids Gynecological surgery biology business.industry Uterus Obstetrics and Gynecology Uterine horns medicine.disease Chinchilla rabbit Surgery Solutions Glucose Reproductive Medicine chemistry Carboxymethylcellulose Sodium Models Animal Female Rabbits business |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 120:222-226 |
| ISSN: | 0301-2115 |
| DOI: | 10.1016/j.ejogrb.2004.09.011 |
| Popis: | Objective: The purpose of this study was to assess the ability of four different either solid or fluid barriers to reduce adhesions in an established model of gynecological surgery. Study design: 50 Chinchilla rabbits underwent bilateral deperitonealization and devascularization of the uterine horns (DUH). Afterwards solid membranes of either hyaluronic acid-carboxymethylcellulose (HA-CMC) or lactide-caprolactone-copolymer (LCC) were placed around the injured uterine horns or fluids (icodextrin (ID) or phospholipids (PL)) were intraperitonealy administered. The control group went without protection. After 10 days, adhesions were measured by planimetry. Results: Phospholipids (median 49.8 mm 2 ) significantly reduced adhesion areas in comparison to all other groups: surgical controls (median 230.6 mm 2 ), HA-CMC (median 194.9 mm 2 ), LCC (median 327.1 mm 2 ), and icodextrin (median 242.1 mm 2 ). Conclusions: These results prove the efficacy of phospholipids to reduce primary adhesion formation in the Chinchilla double uterine horn model compared to HA-CMC, LCC and icodextrin. Future clinical studies are recommended. |
| Databáze: | OpenAIRE |
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