Immediate-early protein of pseudorabies virus is not continuously required to reinitiate transcription of induced genes
| Autor: | L T Feldman, S E Ahlers |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Genes
Viral Transcription Genetic Immunology Response element E-box Biology Microbiology Immediate early protein Immediate-Early Proteins Viral Proteins Sp3 transcription factor Virology Humans General transcription factor Temperature Nucleic Acid Hybridization Promoter TCF4 Cell Transformation Viral Molecular biology Herpesvirus 1 Suid Genes Insect Science TAF2 HeLa Cells Research Article |
| Zdroj: | Journal of virology. 61(4) |
| ISSN: | 0022-538X |
| Popis: | We examined the role of herpesvirus immediate-early proteins in inducing and maintaining transcription by using tsG, a temperature-sensitive mutant in the immediate-early gene of pseudorabies virus. Cells infected at the permissive temperature were shifted to the nonpermissive temperature. Initially, early gene transcription rates were similar at both temperatures. Early gene transcription subsequently decreased slowly over several hours. Our results suggest that immediate-early protein function is required only for the initial activation of early gene transcription and is not required for multiple reinitiation events from activated early genes. |
| Databáze: | OpenAIRE |
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