Hepatitis B Virus Infection and Intrahepatic Cholangiocarcinoma in Korea: A Case-Control Study
| Autor: | Sung K Lee, Dong Jin Suh, Hyoung-Chul Oh, Dong W Seo, Myung-Hwan Kim, Seunghyun Kwon, Sung-Cheol Yun, Seok Won Jung, Seong H Jeon, Tae Y Lee, Sang S Lee |
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| Rok vydání: | 2008 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Alcohol Drinking viruses Lithiasis medicine.disease_cause digestive system Gastroenterology Cholangiocarcinoma Diabetes Complications Risk Factors Internal medicine medicine Animals Humans neoplasms Intrahepatic Cholangiocarcinoma Hepatitis B virus Clonorchis sinensis Korea Hepatology biology business.industry Liver Diseases Case-control study Cancer Viral hepatitis b Hepatitis C Hepatitis C Chronic Middle Aged Hepatitis B medicine.disease biology.organism_classification Virology digestive system diseases Bile Ducts Intrahepatic Bile Duct Neoplasms Case-Control Studies Choledochal Cyst Clonorchiasis Female Viral disease business |
| Zdroj: | The American Journal of Gastroenterology. 103:1716-1720 |
| ISSN: | 1572-0241 0002-9270 |
| DOI: | 10.1111/j.1572-0241.2008.01796.x |
| Popis: | There is a wide variation in risk factors for intrahepatic cholangiocarcinoma (ICC) among various populations. Several studies have suggested that hepatitis C virus (HCV) infection may play a role in the development of ICC, whereas the role of hepatitis B virus (HBV) infection is less clear.To determine whether HBV or HCV infection is a risk factor of ICC, we compared baseline demographic and clinical factors in 622 patients diagnosed between 2000 and 2004 with histologically confirmed ICC and 2,488 healthy controls, matched 4:1 with ICC patients for sex and year of birth.HBV infection (odds ratio [OR] 2.3, 95% confidence interval [CI] 1.6-3.3), but not HCV infection, was significantly related to ICC. Other significant risk factors for ICC included liver cirrhosis (OR 13.6), heavy alcohol consumption (OR 6.6), diabetes (OR 3.2), Clonorchis sinensis infection (OR 13.6), hepatolithiasis (OR 50.0), and choledochal cysts (OR 10.7).Our results indicate that development of ICC seems to be more closely related to HBV infection than to HCV infection in Korea, where both HBV and ICC are endemic. |
| Databáze: | OpenAIRE |
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