Predictors for gut colonization of carbapenem-resistant Enterobacteriaceae in neonates in a neonatal intensive care unit
| Autor: | Prerna Batra, Vikas Manchanda, Narendra Pal Singh, Rituparna Saha, Debapriya Das Choudhury, Sumit Rai, Kavita Gupta, Iqbal R Kaur |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Neonatal intensive care unit Epidemiology medicine.drug_class Birth weight 030106 microbiology Antibiotics Breastfeeding Carbapenem-resistant enterobacteriaceae 030501 epidemiology 03 medical and health sciences Risk Factors Internal medicine Intensive Care Units Neonatal medicine Humans Colonization Gut colonization business.industry Health Policy Public Health Environmental and Occupational Health Enterobacteriaceae Infections Infant Newborn Gastrointestinal Tract Infectious Diseases Carbapenem-Resistant Enterobacteriaceae Carrier State Gestation 0305 other medical science business |
| Zdroj: | American journal of infection control. 46(6) |
| ISSN: | 1527-3296 |
| Popis: | Background With the emergence of carbapenem-resistant isolates, the therapeutic alternatives have become limited. Various factors are responsible for carbapenem-resistant Enterobacteriaceae (CRE) gut colonization. This study was conducted to determine predictors for CRE gut colonization in neonates who were hospital delivered and admitted in a neonatal intensive care unit (NICU). Methods Three rectal swabs were collected from 300 hospital-delivered and NICU-admitted neonates (likely to stay for >3 days). The data collected for the possible risk factors for CRE gut colonization were namely mode of delivery, prolonged rupture of membrane >18 hours, period of gestation, birth weight, meconium-stained liquor, ventilation, intravenous catheter, nasogastric (NG) tube, NG feeding, breastfeeding, katori spoon feeding, top feeding, expressed breastmilk, antibiotics administration, and duration of hospitalization. P Results A total of 26 cases of CRE were isolated from 300 neonates. Statistically significant risk factors were found to be NG tube, breastfeeding, NG feeding, top feeding, expressed breastmilk, ventilation, antibiotic administration, and duration of hospitalization. Top feeding and antibiotics administration were identified as 2 independent risk factors by multiple logistic regression. Conclusions Active surveillance of cultures from hospitalized patients and implementation of preventive efforts can reduce the risk of CRE. |
| Databáze: | OpenAIRE |
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