Susceptibility to Breast Cancer and Three Polymorphisms of GSTZ1
| Autor: | Iraj Saadat, Samane Nafissi, Maryam Khalili, Mostafa Saadat, Shahpour Omidvari |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Oncology
medicine.medical_specialty Linkage disequilibrium Breast Neoplasms Dichloroacetic acid GSTZ1 Biology medicine.disease_cause Polymorphism Single Nucleotide chemistry.chemical_compound Breast cancer Internal medicine Genetics medicine Humans Genetic Predisposition to Disease Molecular Biology Glutathione Transferase Cancer Cell Biology General Medicine Glutathione medicine.disease Endocrinology Haplotypes chemistry Female Xenobiotic Oxidative stress |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1557-7430 1044-5498 |
| DOI: | 10.1089/dna.2011.1334 |
| Popis: | Glutathione S-transferases class zeta (GSTζ) is involved in the detoxification of xenobiotic compounds and catalyzes the biotransformation of a variety of α-haloacids including dichloroacetic acid and chlorofluoroacetic acid. It has been reported that, in mice, deficiency of Gstz1 (a member of GSTζ) resulted in the generation of a constant level of oxidative stress. The present study was carried out to investigate the association between genetic polymorphisms of GSTZ1 (in promoter site G-1002A and in coding sites Glu32Lys and Gly42Arg) and risk of breast cancer. We included 106 females with breast cancer and 106 healthy females frequency matched for age. The study polymorphisms were not associated with risk of breast cancer (p0.05). The polymorphisms of GSTZ1 showed strong linkage disequilibrium among cancer patients and control subjects (p0.0001). There was no significant difference between cancer patients and controls for frequencies of the GSTZ1 haplotypes (p0.05). It seems there is no meaningful relationship between the genetic polymorphisms of GSTZ1 and risk of breast cancer. |
| Databáze: | OpenAIRE |
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