Cost-effectiveness of topiramate in migraine prevention: results from a pharmacoeconomic model of topiramate treatment
| Autor: | Joseph Menzin, Jeffrey S. Brown, Jeffrey D. Miller, Mark N. Friedman, Peter J. Neumann, George Papadopoulos |
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| Rok vydání: | 2005 |
| Předmět: |
Topiramate
medicine.medical_specialty Total cost Cost effectiveness Cost-Benefit Analysis Migraine Disorders Fructose Indirect costs medicine Humans Economics Pharmaceutical Adverse effect health care economics and organizations Randomized Controlled Trials as Topic business.industry Decision Trees medicine.disease United States Discontinuation Neurology Migraine Emergency medicine Physical therapy Neurology (clinical) Headaches medicine.symptom business Models Econometric medicine.drug |
| Zdroj: | Headache. 45(8) |
| ISSN: | 0017-8748 |
| Popis: | OBJECTIVE Patients whose migraines are frequent, cause disruptions of daily routines, or are unresponsive to acute treatment are primary candidates for preventive migraine therapy. This cost-effectiveness model assesses the clinical and economic impact of topiramate (TPM) therapy versus no preventive treatment for migraine headache in the United States. BACKGROUND Despite significant progress in treatment options, the economic burden of migraine to patients, employers, health systems, and society is substantial. Treatment strategies for migraine are directed toward managing acute episodes. However, preventive therapy should be used for patients with frequent migraine attacks (>2 per month) or those experiencing attacks that disrupt daily routines. METHODS Data for the model were obtained from the published literature and pooled results of two randomized, double-blinded, placebo-controlled trials of TPM in migraine prevention. Model inputs included baseline migraine frequency (the base case assumed 6 per month, consistent with the average rate in the TPM trials), treatment discontinuation (including discontinuation due to adverse events), treatment response (ie, > or = 75%, 50% to 75%, and |
| Databáze: | OpenAIRE |
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