Bauerenol Acetate, the Pentacyclic Triterpenoid from Tabernaemontana longipes, is an Antitrypanosomal Agent
| Autor: | William N. Setzer, HaJeung Park, Simira Carothers, Huaisheng Zhang, Rogers Nyamwihura, Ifedayo Victor Ogungbe, Jasmine T. Collins |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
trypanosomiasis Magnetic Resonance Spectroscopy Cell Survival Tabernaemontana Antiparasitic medicine.drug_class Trypanosoma brucei brucei 030106 microbiology Pharmaceutical Science Tabernaemontana longipes Trypanosoma brucei Article Analytical Chemistry Terpene lcsh:QD241-441 03 medical and health sciences chemistry.chemical_compound Parasitic Sensitivity Tests lcsh:Organic chemistry Cell Line Tumor Drug Discovery medicine Humans Physical and Theoretical Chemistry Trypanocidal agent Chloroform Molecular Structure biology Plant Extracts Organic Chemistry biology.organism_classification Trypanocidal Agents Antiparasitic agent Triterpenes 030104 developmental biology chemistry Biochemistry Chemistry (miscellaneous) Molecular Medicine pentacyclic triterpenoid |
| Zdroj: | Molecules, Vol 23, Iss 2, p 355 (2018) Molecules (Basel, Switzerland) |
| ISSN: | 1420-3049 |
| Popis: | The Latin American plant Tabernaemontana longipes was studied in this work as a potential source of antiparasitic agents. The chloroform extract of T. longipes leaves was separated into several fractions, and tested for antitrypanosomal activity. One of the fractions displayed significant growth inhibitory activity against Trypanosoma brucei. The active principle in the fraction was isolated, purified, and characterized by NMR and mass spectrometry. The antitrypanosomal agent in the CHCl3 extract of T. longipes leaves is the pentacyclic triterpenoid bauerenol acetate. A metabolite profiling assay suggest that the triterpenoid influences cholesterol metabolism. The molecular target(s) of bauerenol and its acetate, like many other antiparasitic pentacyclic triterpenoids is/are unknown, but they present privileged structural scaffolds that can be explored for structure-based activity optimization studies using phenotypic assays. |
| Databáze: | OpenAIRE |
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