Synthetic strategies for preparation of cyclen-based MRI contrast agents

Autor:	Goran Angelovski, Serhat Gündüz, Rathikrishnan Rengarasu, Nevenka Cakić
Jazyk:	angličtina
Předmět:	Lanthanide medicine.diagnostic_test Stereochemistry Organic Chemistry Magnetic resonance imaging Lanthanide complexes Biochemistry Combinatorial chemistry chemistry.chemical_compound Macrocyclic ligands Cyclen chemistry Drug Discovery medicine Chelation
Zdroj:	Tetrahedron Letters
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2014.12.087
Popis:	Cyclen-based macrocyclic ligands have an essential role in the development of contrast agents for magnetic resonance imaging (MRI). A prevailing need for preparation of multifunctional probes triggered a number of attempts to synthesize and derivatize ligands which efficiently chelate lanthanide ions and have advantageous MRI properties. This digest Letter summarizes the most common synthetic approaches for the preparation of macrocyclic ligands based on cyclen depending on the desired application.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a84a5e69182aea4e6670301a95e086 Zobrazit plný text záznamu