Inhibitory components from the buds of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells
| Autor: | Kuniyoshi Shimizu, Ryuichiro Kondo, Enos Tangke Arung, Irawan Wijaya Kusuma, Eri Matsubara, Edi Sukaton |
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| Rok vydání: | 2010 |
| Předmět: |
Syzygium
Cell Melanoma Experimental Flowers Pharmacology Acetates Essential oil Melanin inhibition law.invention Melanin chemistry.chemical_compound Mice law Cell Line Tumor Drug Discovery Eugenol medicine Oils Volatile Animals Cytotoxicity neoplasms Melanins biology Eugenol acetate Plant Extracts Melanoma General Medicine biology.organism_classification medicine.disease B16 melanoma cells Syzygium aromaticum medicine.anatomical_structure chemistry Biochemistry Cell culture Dermatologic Agents |
| Zdroj: | Fitoterapia. 82(2) |
| ISSN: | 1873-6971 |
| Popis: | In the course to find a new whitening agent, we evaluated the methanol extract from bud of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells. Eugenol and eugenol acetate were isolated as the active compounds and showed melanin inhibition of 60% and 40% in B16 melanoma cell with less cytotoxicity at the concentration of 100 and 200 μg/mL, respectively. Furthermore, an essential oil prepared from the bud of clove, which contain eugenol and eugenol acetate as dominant components, showed melanin inhibition of 50% and 80% in B16 melanoma cells at the concentration of 100 and 200 μg/mL, respectively. |
| Databáze: | OpenAIRE |
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