Association between maternal exposure to tobacco, presence of TGFA gene, and the occurrence of oral clefts. A case control study
| Autor: | Mohammed Junaid, SG Ramesh Kumar, A. Leena Selvamary, D Jayanthi, MB Aswath Narayanan |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Passive smoking Cleft Lip Dentistry Disease medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Risk Factors Surveys and Questionnaires medicine Humans 030212 general & internal medicine Allele General Dentistry Alleles Polymorphism Genetic Obstetrics business.industry Infant Newborn Case-control study Infant 030206 dentistry Odds ratio Transforming Growth Factor alpha Cleft Palate Maternal Exposure Case-Control Studies Gestation Female Tobacco Smoke Pollution Gene polymorphism Restriction fragment length polymorphism business Polymorphism Restriction Fragment Length |
| Zdroj: | Clinical Oral Investigations. 22:217-223 |
| ISSN: | 1436-3771 1432-6981 |
| Popis: | To determine the association between maternal tobacco use or exposure, presence of variant transforming growth factor alpha (TGFA) gene, and the occurrence of oral clefts. The present case control study was carried out for 5 months in three tertiary government hospitals in Chennai city with a sample of 100 children (50 children with non syndromic cleft and 50 control) aged 0–24 months. The details of maternal risk factors during the period of gestation were recorded from case and control parents through a pre-validated questionnaire, following which blood samples from 92 children (46 case and 46 controls) based on consent were obtained and evaluated for TGFA gene polymorphism. A significant number of case mothers (48%) were exposed to secondhand smoke during the period of gestation than their control counterparts (24%) (P = 0.01) with an odds ratio of 2.46 (95% CI = 0.99–6.08). Electrophoresis of the restriction fragment length polymorphism (RFLP) product revealed the presence of the homozygous C1C1 allele in all the tested 92 samples with no homozygous C2C2 allele or heterozygous C1C2 allele. The present study has highlighted the role of passive smoking in the causation of non syndromic oral clefts in a developing country like India; however, the involvement of TGFA in causing the same disease in an ethnically Dravidian Indian population is uncertain. The study has brought into forth the role of passive smoking in the development of oral clefts thereby warranting an effective public health policy to tackle the same. |
| Databáze: | OpenAIRE |
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