Epidemiology of moderately severe and severe non-proliferative diabetic retinopathy in South West England

Autor: Irene M Stratton, Elvira L Massó-González, Sonia S Maruti, Clare Bailey, Peter H Scanlon, Victor Chong, Michael Ehrlich, Sobha Sivaprasad, Clareece R Nevill
Rok vydání: 2021
Předmět:
Zdroj: Eye
ISSN: 1476-5454
0950-222X
DOI: 10.1038/s41433-021-01471-8
Popis: Aims To estimate the incidence of early treatment diabetic retinopathy study (ETDRS) level 47 and 53 and progression to treatment with panretinal photocoagulation (PRP) for proliferative DR (PDR). Methods Log-linear regression was used to estimate the incidence of level 47–53 or worse for 33,009 people with diabetes (PWD) in Gloucestershire during 2013–2016 by calendar year and diabetes type, based on the first recording. Progression was analysed in Gloucestershire and Bristol with a parametric survival analysis examining the association of baseline and time-varying demographic and clinical factors on time to PRP after the first recording of level 47–53. Results Incidence decreased from 0.57 (95% confidence intervals (CI) 0.48–0.67) per 100 PWD in 2013 to 0.35 (95% CI 0.29–0.43) in 2016 (p 1c were associated with an increase in the risk of initiating PRP (hazard ratio 3.14 (95% CI: 1.60–6.15) and 1.21 (95% CI: 1.06–1.38 per 10 mmol/mol) respectively). Conclusion This study provides additional understanding of this population and shows that a high proportion of patients with ETDRS levels 47–53 need to be monitored as they are at high risk of progressing to PDR.
Databáze: OpenAIRE
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