Uterine Transplantation: Review of Livebirths and Reproductive Implications
| Autor: | Timothy Bracewell-Milnes, Saaliha Vali, Sadaf Ghaem-Maghami, Liza Johannesson, J. Richard Smith, Joseph Yazbek, Maria Jalmbrant, B. Jones, Benjamin P Jones, Meen-Yau Thum, Lorraine Kasaven, Peter J. Friend, Isabel Quiroga, Cesar Diaz-Garcia, Christoph Lees, Srdjan Saso, Giuliano Testa |
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| Rok vydání: | 2020 |
| Předmět: |
Infertility
Adult medicine.medical_specialty Demographics media_common.quotation_subject Fertility Fertilization in Vitro 030230 surgery 03 medical and health sciences Uterine transplantation 0302 clinical medicine Pregnancy medicine Humans Pregnancy outcomes Preterm delivery media_common Transplantation Fetus business.industry Obstetrics Patient Selection Uterus Infant Newborn Organ Transplantation Middle Aged medicine.disease Tissue Donors Small for gestational age 030211 gastroenterology & hepatology Female business Live Birth |
| Zdroj: | Transplantation. 105(8) |
| ISSN: | 1534-6080 |
| Popis: | Uterine transplantation (UTx) is a fertility restoring treatment for women with absolute uterine factor infertility. At a time when there is no question of the procedure's feasibility, and as the number of livebirths begins to increase exponentially, various important reproductive, fetal and maternal medicine implications have emerged. Detailed outcomes from 17 livebirths following UTx are now available, which are reviewed herein, along with contextualized extrapolation from pregnancy outcomes in other solid organ transplants. Differences in recipient demographics and reproductive aspirations between UTx and other transplant recipients make extrapolating management strategies and outcomes in other solid organ transplants inappropriate. Whereas preterm delivery remains prominent, small for gestational age or hypertensive disorders do not appear to be as prevalent following UTx when compared to other solid organ transplants. Given the primary objective of undertaking UTx is to achieve a livebirth, publication of reproductive outcomes is essential at this early stage, to reflect upon and optimize the management of future cases. |
| Databáze: | OpenAIRE |
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