Nutlin-loaded magnetic solid lipid nanoparticles for targeted glioblastoma treatment

Autor: Edoardo Sinibaldi, Mario Giorgi, César de Julián Fernández, Agostina Grillone, Alice Scarpellini, Stefania Moscato, Matteo Battaglini, Letizia Mattii, Gianni Ciofani
Jazyk: angličtina
Rok vydání: 2019
Předmět:
in vitro blood-brain barrier model
Medicine (miscellaneous)
02 engineering and technology
blood–brain barrier
Piperazines
chemistry.chemical_compound
General Materials Science
Free drug
blood-brain barrier
dynamic fluidic models
glioblastoma multiforme
magnetic targeting
nutlin-3a
solid lipid nanoparticles
Bioengineering
Biomedical Engineering
Materials Science (all)
Magnetite Nanoparticles
Drug Carriers
0303 health sciences
Chemistry
Imidazoles
Nutlin
021001 nanoscience & nanotechnology
Lipids
3. Good health
0210 nano-technology
Cell Survival
Surface Properties
Antineoplastic Agents
Development
Superparamagnetic nanoparticles
Article
03 medical and health sciences
Cell Line
Tumor
Solid lipid nanoparticle
medicine
Humans
Particle Size
030304 developmental biology
Biological Transport
medicine.disease
superparamagnetic nanoparticles
Nutlin 3a
body regions
Drug Liberation
Kinetics
Delivery efficiency
Cancer research
Glioblastoma
Zdroj: Nanomedicine (London, England)
Nanomedicine
Nanomedicine (Lond., Print) (2019). doi:10.2217/nnm-2018-0436
info:cnr-pdr/source/autori:Agostina Grillone, Matteo Battaglini, Stefania Moscato, Letizia Mattii, César de Julián Fernández, Alice Scarpellini, Mario Giorgi, Edoardo Sinibaldi, Gianni Ciofani/titolo:Nutlin-loaded magnetic solid lipid nanoparticles for targeted glioblastoma treatment/doi:10.2217%2Fnnm-2018-0436/rivista:Nanomedicine (Lond., Print)/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume
DOI: 10.2217/nnm-2018-0436
Popis: Aim: Glioblastoma multiforme is one of the deadliest forms of cancer, and current treatments are limited to palliative cares. The present study proposes a nanotechnology-based solution able to improve both drug efficacy and its delivery efficiency. Materials & methods: Nutlin-3a and superparamagnetic nanoparticles were encapsulated in solid lipid nanoparticles, and the obtained nanovectors (nutlin-loaded magnetic solid lipid nanoparticle [Nut-Mag-SLNs]) were characterized by analyzing both their physicochemical properties and their effects on U-87 MG glioblastoma cells. Results: Nut-Mag-SLNs showed good colloidal stability, the ability to cross an in vitro blood–brain barrier model, and a superior pro-apoptotic activity toward glioblastoma cells with respect to the free drug. Conclusion: Nut-Mag-SLNs represent a promising multifunctional nanoplatform for the treatment of glioblastoma multiforme.
Databáze: OpenAIRE
Externí odkaz: