Polymorphism of insulin-like growth factor 1 gene and its relationship with reproductive performances and milk yield in Sarda dairy sheep
| Autor: | Cosso Giovanni, Luridiana Sebastiano, Nehme Michella, Di Stefano Maria Veronica, Pulinas Luisa, Carcangiu Vincenzo, Mura Maria Consuelo |
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| Rok vydání: | 2020 |
| Předmět: |
Litter (animal)
040301 veterinary sciences Reproductive performances Article 0403 veterinary science Exon Animal science Polymorphism (computer science) Lactation medicine Allele Gene IGF-1 gene polymorphisms lcsh:Veterinary medicine General Veterinary biology Domestic sheep reproduction 0402 animal and dairy science Sarda sheep 04 agricultural and veterinary sciences biology.organism_classification 040201 dairy & animal science medicine.anatomical_structure lcsh:SF600-1100 Animal Science and Zoology Sarda |
| Zdroj: | Veterinary and Animal Science Veterinary and Animal Science, Vol 9, Iss, Pp 100084-(2020) |
| ISSN: | 2451-943X |
| Popis: | Highlights • IGF-1 gene plays an important role in regulating reproduction in ruminants. • Here three SNPs were found in the IGF-I gene in Sarda sheep. • The found SNPs were related to reproductive performance and milk yield. • This results could be used to improve the reproductive performances and milk yield in Sarda sheep. The aim of this research was to detect polymorphisms within the IGF-I gene in dairy sheep and to verify their influence on milk yield and reproductive performances. Four hundred Sarda ewes in their second lactation were selected from 2 farms. Their reproductive traits (fertility rate, interval in days from ram introduction to lambing and litter size) and milk yield were recorded, from the second to the fourth lactation. DNA was extracted from individual blood samples and subjected to amplification and sequencing of the IGF-I gene 5′ UTR and Exon 3 regions. Three polymorphic sites were recorded at positions g184028491C>G and g184028489C>T of the 5′UTR, and g184023223G>A of the Exon 3. The C allele at position g184028491 showed a significant association with higher fertility rate (P |
| Databáze: | OpenAIRE |
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