Immunoreactive atrial natriuretic factor in aqueous humor: Its concentration is increased with high intraocular pressure in rabbit eyes
| Autor: | José Ramírez, Juan J. Salazar, Ana I. Ramírez, Arturo Fernández-Cruz, R. Fernandez-Durango, J. Gutkowska, Alberto Triviño, M. Garcia de Lacoba |
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| Rok vydání: | 1990 |
| Předmět: |
Male
Intraocular pressure medicine.medical_specialty genetic structures Glaucoma Aqueous humor Eye Aqueous Humor Atrial natriuretic peptide Ophthalmology medicine Animals Chymotrypsin Lagomorpha biology Chemistry medicine.disease Natriuretic hormone biology.organism_classification eye diseases Sensory Systems Rabbits sense organs High intraocular pressure Atrial Natriuretic Factor |
| Zdroj: | Vision Research. 30:1305-1310 |
| ISSN: | 0042-6989 |
| DOI: | 10.1016/0042-6989(90)90004-5 |
| Popis: | Atrial natriuretic factor (ANF) concentration in the aqueous humor (AH) was studied in rabbits with experimental glaucoma induced by injecting alpha-chymotrypsin into the posterior chamber. In normal rabbit eyes, the ANF concentration in AH was 3.1 +/- 1.2 pg/ml (mean +/- SEM; n = 12), ranging from 0 to 5.8 pg/ml, whereas it was significantly higher in AH from glaucomatous rabbit eyes, being 81.0 +/- 9.8 pg/ml (n = 12). These findings were correlated with intraocular pressure (IOP), which was 13.0 +/- 2.4 mmHg (n = 12) in normal rabbit eyes and significantly greater in glaucomatous eyes: 24.4 +/- 3.0 mmHg (n = 12). Our data indicate that enhanced ANF release in AH during experimental glaucoma may play an important physiological role in modulating IOP. |
| Databáze: | OpenAIRE |
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