Measurement of Myocardial Oxygen Tension: A Valid and Sensitive Method in the Investigation of Transmyocardial Laser Revascularization in an Acute Ischemia Model
| Autor: | D. Sedding, T. Stadlbauer, Martin Heidt, Andreas Boening, M. Schönburg, P. R. Vogt, S. K. H. Stracke |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Swine Partial Pressure Myocardial Ischemia Ischemia Contrast Media Microcirculation Coronary circulation Polysaccharides Coronary Circulation Internal medicine Electrochemistry Laser-Doppler Flowmetry Myocardial Revascularization medicine Animals Myocardial infarction business.industry Myocardium Reproducibility of Results Laser Doppler velocimetry medicine.disease Oxygen tension Oxygen Disease Models Animal medicine.anatomical_structure Echocardiography Coronary occlusion Acute Disease Cardiology Lasers Excimer Surgery Laser Therapy Cardiology and Cardiovascular Medicine business Perfusion Ion-Selective Electrodes |
| Zdroj: | The Thoracic and Cardiovascular Surgeon. 57:79-84 |
| ISSN: | 1439-1902 0171-6425 |
| DOI: | 10.1055/s-2008-1039209 |
| Popis: | BACKGROUND: The effect of transmyocardial laser revascularization (TMLR) on microperfusion and oxygen supply was studied in an acute ischemia model, using 35 pigs, with 13 serving as controls. METHODS: Measurement of tissue oxygen tension was compared with the semiquantitative measurement of microperfusion using contrast echocardiography and infrared laser Doppler. All methods were used before and after coronary occlusion and after TMLR. Effects were measured in the ischemic area and in two ischemia independent areas. RESULTS: At baseline, oxygen partial pressure was 54.2 +/- 15.7 mmHg and decreased to 2.8 +/- 1.4 mmHg ( P < 0.05) after occlusion. After TMLR, oxygen tension increased to 27.3 +/- 8.5 mmHg ( P < 0.05) in the ischemic area, indicating a significant effect of TMLR on microperfusion and oxygen tension. Changes in regional oxygen tension corresponded to Levovist density changes in contrast echocardiography and changes in microperfusion measured by infrared laser Doppler. CONCLUSIONS: Our data indicate that measurement of tissue oxygen tension is a suitable experimental tool to assess the effect of TMLR on myocardial perfusion, which cannot be discriminated using clinical imaging methods. |
| Databáze: | OpenAIRE |
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