Allelic Variation in Taste Genes Is Associated with Taste and Diet Preferences and Dental Caries
| Autor: | Linda Eriksson, Anders Esberg, Ingegerd Johansson, Pernilla Lif Holgerson, Simon Haworth |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Taste Odontologi Diet preference Receptors G-Protein-Coupled TAS1R1 0302 clinical medicine Gene Frequency TAS1R2 Risk Factors Taste receptor Caries Food science Diet selection Glucose Transporter Type 2 Glucose Transporter Type 4 Nutrition and Dietetics GNAT3 digestive oral and skin physiology Sweetness Näringslära Phenotype Female lcsh:Nutrition. Foods and food supply diet preference Adolescent lcsh:TX341-641 Taste genes Dental Caries Biology Polymorphism Single Nucleotide Article Young Adult 03 medical and health sciences stomatognathic system Humans Genetic Predisposition to Disease Taste Threshold Transducin Taste perception caries Sweden Feeding Behavior 030206 dentistry Gustducin Taste preference taste genes 030104 developmental biology Dentistry taste preference diet selection taste perception Food Science |
| Zdroj: | Nutrients, Vol 11, Iss 7, p 1491 (2019) Eriksson, L, Esberg, A, Haworth, S, Holgerson, P L & Johansson, I 2019, ' Allelic variation in taste genes is associated with taste and diet preferences and dental caries ', Nutrients, vol. 11, no. 7, 1491 . https://doi.org/10.3390/nu11071491, https://doi.org/10.3390/nu11071491 Nutrients Volume 11 Issue 7 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu11071491 |
| Popis: | Taste and diet preferences are complex and influenced by both environmental and host traits while affecting both food selection and associated health outcomes. The present study genotyped 94 single nucleotide polymorphisms (SNPs) in previously reported taste and food intake related genes and assessed associations with taste threshold (TT) and preferred intensity (PT) of sweet, sour and bitter, food preferences, habitual diet intake, and caries status in healthy young Swedish men and women (n = 127). Polymorphisms in the GNAT3, SLC2A4, TAS1R1 and TAS1R2 genes were associated with variation in TT and PT for sweet taste as well as sweet food intake. Increasing PT for sweet was associated with increasing preference and intake of sugary foods. Similarly, increasing TT for sour was associated with increasing intake of sour foods, whereas the associations between food preference/intake and TT/PT for bitter was weak in this study group. Finally, allelic variation in the GNAT3, SLC2A2, SLC2A4, TAS1R1 and TAS1R2 genes was associated with caries status, whereas TT, PT and food preferences were not. It was concluded that variations in taste receptor, glucose transporter and gustducin encoding genes are related to taste perception, food preference and intake as well as the sugar-dependent caries disease. |
| Databáze: | OpenAIRE |
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