Human pharmacology of renzapride: a new gastrokinetic benzamide without dopamine antagonist properties
| Autor: | D. H. Staniforth, M. Pennick |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Bridged-Ring Compounds Male medicine.medical_specialty Metoclopramide Biology Pharmacology Bridged Bicyclo Compounds Random Allocation Lactulose chemistry.chemical_compound Pharmacokinetics Internal medicine medicine Humans Pharmacology (medical) Gastrointestinal Transit Benzamide Gastric emptying digestive oral and skin physiology Dopamine antagonist General Medicine Bridged Bicyclo Compounds Heterocyclic Prolactin Renzapride Stomach emptying Endocrinology Breath Tests Gastric Emptying chemistry Dopamine receptor Benzamides medicine.drug |
| Zdroj: | European Journal of Clinical Pharmacology. 38 |
| ISSN: | 1432-1041 0031-6970 |
| DOI: | 10.1007/bf00265977 |
| Popis: | The activity of the substituted benzamide renzapride on the upper gastrointestinal tract has been investigated. It has been shown to enhance stomach emptying in normal subjects; doses of 2 and 5 mg decreasing by 21 and 37% respectively the volume of gastric contents aspirated 80 min after a test meal. Renzapride was found to reduce the oro-caecal transit time as assessed by the lactulose/breath hydrogen method in a dose related manner from 0.2 to 5 mg; the later dose producing a 62% reduction. Finally renzapride was shown not to elevate plasma prolactin at a dose of 5 mg, a finding consistent with lack of dopamine receptor antagonism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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