Agranulocytosis during antibiotic therapy: drug sensitivity or sepsis?
| Autor: | Anthony V. Pisciotta |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Drug
Adult Male medicine.drug_class media_common.quotation_subject Antibiotics Granulocyte Infections Sepsis medicine Humans media_common Leukopenia business.industry Clindamycin Macrophages Stem Cells Hematology medicine.disease Respiratory burst Anti-Bacterial Agents medicine.anatomical_structure Toxicity Immunology Female medicine.symptom business medicine.drug Agranulocytosis Granulocytes |
| Zdroj: | American journal of hematology. 42(1) |
| ISSN: | 0361-8609 |
| Popis: | Forty-three patients reviewed from the literature and five cases of agranulocytosis during antibiotic therapy studied by the author are presented. Time required to develop agranulocytosis with antibiotics was 40 days required with nonantibiotic drugs. In all, agranulocytosis occurred concomitantly with drug treatment and became normal as treatment was discontinued. Retrospective rechallenge studies suggest that agranulocytosis may be dose related. In all cases PMNs were almost completely deleted and marrows were devoid of granulocyte precursors. In contrast, leukopenia secondary to overwhelming sepsis displayed persisting granulocytes in peripheral blood and marrow. While leukagglutinins were not found in nine cited cases, four serums were toxic to test PMNs as measured by suppression of postphagocytosis respiratory burst. Clindamycin directly suppressed development of CFU-G in one sensitive patient but not in 16 normal controls. The hazard of antibiotics in suppressing granulocytopoiesis is emphasized by these observations. © 1993 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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