Hepatitis C virus infection status and associated factors among a multi-site sample of people who used illicit drugs in the Amazon region

Autor: Emil Kupek, Francisco Junior A. Santos, João Renato Rebello Pinho, Luiz Marcelo L. Pinheiro, Rafael Lima Resque, Nairis Costa Raiol, Juliana Nadia F. Piauiense, Luiz Fernando Almeida Machado, Camila Carla da Silva Costa, Gláucia C. Silva-Oliveira, Yasmin Maria N. Cardoso, José Alexandre Rodrigues de Lemos, Aldemir B. Oliveira-Filho, Benedikt Fischer, Luisa Caricio Martins, Jeruza Ferraz F. Di Miceli, Fabricio Quaresma Silva
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Adult
Male
0301 basic medicine
medicine.medical_specialty
Unprotected Sexual Intercourse
Sexual transmission
Adolescent
Substance-Related Disorders
Epidemiology
Hepatitis C virus
030106 microbiology
Hepacivirus
Real-Time Polymerase Chain Reaction
medicine.disease_cause
lcsh:Infectious and parasitic diseases
03 medical and health sciences
0302 clinical medicine
Medical microbiology
Risk Factors
Environmental health
Genotype
Prevalence
Humans
Medicine
lcsh:RC109-216
030212 general & internal medicine
Amazon
Illicit Drugs
business.industry
virus diseases
Hepatitis C Antibodies
Hepatitis C
digestive system diseases
Spontaneous clearance
Cross-Sectional Studies
Infectious Diseases
Socioeconomic Factors
Parasitology
People who used illicit drugs
Tropical medicine
HCV
Female
business
Brazil
Research Article
Zdroj: BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-10 (2019)
BMC Infectious Diseases
ISSN: 1471-2334
Popis: Background Elevated rates of Hepatitis C Virus (HCV) infection have been reported in epidemiological studies with people who used illicit drugs (PWUIDs) in different Brazilian regions. In Brazil’s Amazon region, studies have already identified the common use of illicit drugs among adolescents and the high prevalence of HCV infections among PWUIDs. However, all studies done with PWUIDs were conducted with small samples and within limited geographic coverage. This study determined the prevalence and risk factors for HCV infection in PWUIDs in the Amazon region, northern Brazil, as well as estimating the prevalence and factors associated with the HCV spontaneous clearance (HSC). Methods This cross-sectional study accessed 1666 PWUIDs from multiple municipalities of the Amazon region. Socio-demographic, economic, drug use and health-related information were collected through interviews. Blood samples collected were tested for the presence of anti-HCV antibodies and RNA-HCV. HCV genotypes were identified by real-time polymerase chain reaction (PCR). Logistic regressions were run to identify factors independently associated with HCV infection status and HSC. Results In total, 577 (34.6%) featured HCV antibodies, of which 384 (23.1%) had active HCV infection and 193 (11.6%) indicated HSC. Genotypes 1 (80.2%) and 3 (18.8%) were detected. HCV infection status was associated with the length of illicit drug use history, factors related to parenteral and sexual transmission, and factors of socio-economic marginalization leading to potential risk activities for HCV. HSC was associated with the ethnic (including indigenous) background of participants. Conclusions High levels of HCV infection were detected in PWUIDs. Genotype 1 was predominant. Intense use of illicit drugs, unprotected sexual intercourse, high number of sexual partners and social marginalization were associated with all HCV infection. HSC was associated with origin (Amazonian-born) and non-white (e.g., Black or Indigenous) of PWUIDs. These findings emphasize the need for improve HCV prevention and control services and care for PWUIDs in the Brazilian Amazon region. Electronic supplementary material The online version of this article (10.1186/s12879-019-4270-2) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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