Cytotoxic Sesterterpenes from Thai Marine Sponge Hyrtios erectus
| Autor: | Chulabhorn Mahidol, Hunsa Prawat, Somsak Ruchirawat, Pittaya Tuntiwachwuttikul, Wirongrong Kaweetripob |
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| Rok vydání: | 2018 |
| Předmět: |
2-furanone derivatives
Aquatic Organisms Magnetic Resonance Spectroscopy Sesterterpenes Hyrtios erectus (CRI 572 and CRI 588) Stereochemistry Pharmaceutical Science Antineoplastic Agents Ether 01 natural sciences Article Manoalide chemistry.chemical_compound Hyrtios erectus Cell Line Tumor Drug Discovery Animals Humans scalarane lcsh:QH301-705.5 Pharmacology Toxicology and Pharmaceutics (miscellaneous) cytotoxic activities Indole test Molecular Structure biology 010405 organic chemistry Diastereomer Thailand biology.organism_classification Porifera 0104 chemical sciences 010404 medicinal & biomolecular chemistry Sponge lcsh:Biology (General) chemistry Spectrophotometry Thorectidae Drug Screening Assays Antitumor manoalides |
| Zdroj: | Marine Drugs, Vol 16, Iss 12, p 474 (2018) Marine Drugs Volume 16 Issue 12 |
| ISSN: | 1660-3397 |
| DOI: | 10.3390/md16120474 |
| Popis: | Four sesterterpenes, erectusolides B, C, D, and seco-manoalide-25-methyl ether, two 2-furanone derivatives, erectusfuranones A and B, together with thirteen known sesterterpenes, (6Z)-neomanoalide-24-acetate, two diastereomers of 24-O-methylmanoalide, luffariolide B, manoalide, (6E)- and (6Z)-neomanoalide, seco-manoalide, scalarafuran, 12-acetylscalarolide, 12-epi-O-deacetyl-19-deoxyscalarin, 12-epi-scalarin, and 12-O-deacetyl-12-epi-scalarin, three indole alkaloids, 5-hydroxy-1H-indole-3-carbaldehyde, hyrtiosine A, and variabine B, and one norterpene, cavernosine were isolated from the marine sponge Hyrtios erectus. Their structures were determined by means of spectroscopic methods and the absolute configurations of the asymmetric centers were determined using the modified Mosher’s method. The cytotoxic activities for the isolated compounds have been reported. |
| Databáze: | OpenAIRE |
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