Serial C-reactive protein measurements in patients treated for suspected abdominal tuberculosis
| Autor: | Amit Kumar, Vishal Sharma, Harjeet Singh, Sandeep Lamoria, Harshal S Mandavdhare |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Tuberculosis Antitubercular Agents India Disease Gastroenterology Abdominal tuberculosis Diagnosis Differential Tertiary Care Centers 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine Ascites Drug Resistance Bacterial medicine Humans In patient Retrospective Studies Hepatology biology medicine.diagnostic_test business.industry C-reactive protein Middle Aged medicine.disease Lymphoma Endoscopy C-Reactive Protein Tuberculosis Gastrointestinal 030220 oncology & carcinogenesis biology.protein 030211 gastroenterology & hepatology Female medicine.symptom business |
| Zdroj: | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 50(6) |
| ISSN: | 1878-3562 |
| Popis: | Background Response to treatment is often used as a criterion for the diagnosis of abdominal tuberculosis. Aim To determine utility of serum C reactive protein (CRP) in assessment of response to anti-tubercular therapy (ATT) in abdominal tuberculosis (ATB). Methods We retrospectively analysed the database of patients with suspected ATB (intestinal and/or peritoneal). Response to ATT was assessed using subjective and objective (ulcer healing or ascites resolution) parameters. Serum CRP levels were estimated at baseline and then at 2 months and 6 months of ATT. Results One hundred and twelve patients were included in the analysis. The mean age was 36.57 ± 15.04 years and 54.46% (61/112) were males. Sixty-six patients (58.92%) had intestinal, 28 (25%) had peritoneal and 18 (16.07%) had both. Eleven patients had a normal CRP at baseline while 101 had elevated levels. The CRP levels declined in 94 patients at 6 months. One patient with increased levels at 2 months had multi-drug resistant TB. Seven patients showed elevated or plateaued CRP levels on follow-up. These patients had underlying Crohn’s disease (3 patients), peritoneal carcinomatosis (1), inter-current infection (1), lymphoma (1) and non-healing ulcers (1). Conclusion Lack of decline in CRP may suggest alternative diagnosis or drug-resistant tuberculosis. |
| Databáze: | OpenAIRE |
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