Immune predictors of cancer progression
| Autor: | Jean-Pierre Abastado, Muly Tham, Benjamin Toh, Sandra Hubert, Sumathy Velumani, Xilei Dai, Caleb Huang, Liang Zhi, Karen Khoo, Lu-En Wai, Valerie Chew |
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| Rok vydání: | 2012 |
| Předmět: |
Chemokine
Immunology Mice Transgenic chemical and pharmacologic phenomena Inflammation Mice Immune system Cell Movement Immunity Neoplasms Biomarkers Tumor Tumor Microenvironment medicine Animals Humans Immunologic Surveillance Tumor microenvironment biology CCL18 Cancer biochemical phenomena metabolism and nutrition Prognosis medicine.disease Gene Expression Regulation Neoplastic Immunosurveillance Disease Models Animal Disease Progression biology.protein bacteria Chemokines medicine.symptom |
| Zdroj: | Immunologic Research. 53:229-234 |
| ISSN: | 1559-0755 0257-277X |
| DOI: | 10.1007/s12026-012-8288-4 |
| Popis: | The immune system has multiple, complex, and sometimes opposing roles during cancer progression. While immune-compromised individuals have a higher incidence of cancers, inflammation is also associated with increased risk of disease progression. It is becoming apparent that simple measures of immune responses in the blood are of limited use in cancer. Instead, the importance of the exact identity and functional characteristics of tumor-infiltrating immune cells is increasingly recognized. This realization has led to recent studies that have revealed a critical role for chemokine expression in the tumor microenvironment and suggested a therapeutic potential of manipulating intratumoral expression of chemokines to alter the local immune milieu. |
| Databáze: | OpenAIRE |
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