Mutational biosynthesis by idiotrophs of Micromonospora purpurea. II. Conversion of non-amino containing cyclitols to aminoglycoside antibiotics
| Autor: | S J Daum, W A Ross, D Rosi |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Pharmacology
biology Bacteria Chemical Phenomena Aminoglycoside Mutant biology.organism_classification Micromonospora Microbiology chemistry.chemical_compound Chemistry Biochemistry Biosynthesis chemistry Gentamicin C1 Drug Discovery Mutation medicine Gentamicin Fermentation Gentamicins Antibacterial activity medicine.drug |
| Zdroj: | The Journal of antibiotics. 30(1) |
| ISSN: | 0021-8820 |
| Popis: | A mutant of Micromonospora purpurea, which produces the gentamicin complex only when 2-deoxystreptamine is added to the fermentation medium, produces a new antibiotic complex, 2-hydroxygentamicin, when streptamine or 2, 4, 6/3, 5-pentahydroxycyclohexanone is added to the fermentation medium. This mutant also produces the gentamicin complex when 2, 4/3, 5-tetrahydroxycyclohexanone is added to the fermentation medium. The C1 and C2 components of 2-hydroxygentamicin have broad spectrum in vitro antibacterial activity similar to the gentamicin C1 and C2 components, but with greater activity against some gentamicin-resistant strains. |
| Databáze: | OpenAIRE |
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