Expression of contact-dependent cytolytic activity by Mycobacterium tuberculosis and isolation of the genomic locus that encodes the activity
Autor: | King Ch, Thomas M. Shinnick, J. T. Crawford, Sathish Mundayoor |
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Rok vydání: | 1993 |
Předmět: |
DNA
Bacterial Tuberculosis Bacterial Toxins Immunology Virulence medicine.disease_cause Hemolysis complex mixtures Microbiology Mycobacterium tuberculosis medicine Animals Escherichia coli Mycobacterium bovis Sheep biology Cytotoxins Chromosome Mapping biochemical phenomena metabolism and nutrition biology.organism_classification medicine.disease Virology Bacterial vaccine Cytolysis Infectious Diseases Bacterial Vaccines BCG Vaccine bacteria Parasitology BCG vaccine Research Article |
Zdroj: | Infection and Immunity. 61:2708-2712 |
ISSN: | 1098-5522 0019-9567 |
DOI: | 10.1128/iai.61.6.2708-2712.1993 |
Popis: | We investigated the presence of cytolytic activity in the virulent H37Rv and attenuated H37Ra strains of Mycobacterium tuberculosis and in the vaccine strain Mycobacterium bovis BCG. The virulent strain H37Rv expressed > 3-fold more contact-dependent cytolytic activity than the attenuated strain H37Ra, and the vaccine strain M. bovis BCG did not produce cytolytic activity. We also isolated an approximately 3.2-kbp fragment of the M. tuberculosis H37Rv genome that was capable of inducing this contact-dependent hemolytic activity in a nonhemolytic strain of Escherichia coli. |
Databáze: | OpenAIRE |
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