Expression of contact-dependent cytolytic activity by Mycobacterium tuberculosis and isolation of the genomic locus that encodes the activity

Autor: King Ch, Thomas M. Shinnick, J. T. Crawford, Sathish Mundayoor
Rok vydání: 1993
Předmět:
Zdroj: Infection and Immunity. 61:2708-2712
ISSN: 1098-5522
0019-9567
DOI: 10.1128/iai.61.6.2708-2712.1993
Popis: We investigated the presence of cytolytic activity in the virulent H37Rv and attenuated H37Ra strains of Mycobacterium tuberculosis and in the vaccine strain Mycobacterium bovis BCG. The virulent strain H37Rv expressed > 3-fold more contact-dependent cytolytic activity than the attenuated strain H37Ra, and the vaccine strain M. bovis BCG did not produce cytolytic activity. We also isolated an approximately 3.2-kbp fragment of the M. tuberculosis H37Rv genome that was capable of inducing this contact-dependent hemolytic activity in a nonhemolytic strain of Escherichia coli.
Databáze: OpenAIRE