Serum Expression of Sialyltransferase in Normal and Down's Syndrome-Affected Pregnancy
| Autor: | Kieran C. Breen, Howard Cuckle, Paraskevi Moutsatsou, Kleoniki Liakou |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
endocrine system
medicine.medical_specialty Time Factors Sialyltransferase Clinical Biochemistry Gestational Age Biology Pregnancy Internal medicine Placenta Glycosyltransferase medicine Humans reproductive and urinary physiology chemistry.chemical_classification General Medicine medicine.disease Sialyltransferases Enzyme assay Endocrinology medicine.anatomical_structure Enzyme chemistry Case-Control Studies biology.protein Gestation Female Down Syndrome Trisomy Biomarkers |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1758-1001 0004-5632 |
| DOI: | 10.1177/000456320003700412 |
| Popis: | Human chorionic gonadotrophin (hCG) has been used as a serum biochemical marker of Down's syndrome (DS) pregnancies, and recent studies have reported an increase in a hyperglycosylated form of the protein associated with DS. In the present study, the activity of the combined soluble serum sialyltransferase (ST) enzymes was examined as a potential marker for the hyperglycosylated form of hCG. There were no changes in total ST activity during the course of the pregnancy in normal mothers and there was no difference in enzyme activity in the DS pregnancies when compared with controls. These results suggest that, although there may be an alteration in the activities of one or more of the glycosyltransferase enzymes in the placenta resulting in an alteration in hCG glycosylation, this is not reflected in the serum soluble enzyme activity. |
| Databáze: | OpenAIRE |
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