Association between ionised calcium and severity of postpartum haemorrhage: a retrospective cohort study
| Autor: | Danny Epstein, Erez Marcusohn, Ron Avrahami, Yaacov Freund, Aeyal Raz, Asaf Miller, Ami Neuberger, Alexander Korytny, Neta Solomon |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty macromolecular substances Fibrinogen Severity of Illness Index Cohort Studies 03 medical and health sciences 0302 clinical medicine Emergency surgery 030202 anesthesiology Pregnancy Internal medicine medicine Humans Hypocalcaemia Blood Transfusion Retrospective Studies Hypocalcemia business.industry Vaginal delivery Postpartum Hemorrhage Ionised calcium Retrospective cohort study medicine.disease Postpartum haemorrhage Anesthesiology and Pain Medicine Blood units Calcium Female business medicine.drug |
| Zdroj: | British journal of anaesthesia. 126(5) |
| ISSN: | 1471-6771 |
| Popis: | Background Postpartum haemorrhage (PPH) is often complicated by impaired coagulation. We aimed to determine whether the level of ionised calcium (Ca2+), an essential coagulation co-factor, at diagnosis of PPH is associated with bleeding severity. Methods This was a retrospective cohort study of women diagnosed with PPH during vaginal delivery between January 2009 and April 2020. Ca2+ levels at PPH diagnosis were compared between women who progressed to severe PPH (primary outcome) and those with less severe bleeding. Severe PPH was defined by transfusion of ≥2 blood units, arterial embolisation or emergency surgery, admission to ICU, or death. Associations between other variables (e.g. fibrinogen concentration) and bleeding severity were also assessed. Results For 436 patients included in the analysis, hypocalcaemia was more common among patients with severe PPH (51.5% vs 10.6%, P Conclusions Ca2+ level at the time of diagnosis of PPH was associated with risk of severe bleeding. Ca2+ monitoring may facilitate identification and treatment of high-risk patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|