Nasal polyposis : more than a chronic inflammatory disorder : a disease of mechanical dysfunction : the São Paulo position
| Autor: | Luiz Carlos Gregório, Nathália Coronel, Rodrigo de Paula Santos, Reginaldo Raimundo Fujita, Danilo Almeida Candido, Aldo Cassol Stamm, Wallace Chamon, Juliana L. Dreyfuss, Thibaut Van Zele, Shirley Shizue Nagata Pignatari, Fábio de Rezende Pinna, Fernanda Louise Martinho Haddad, Thiago Freire Pinto Bezerra, José Arruda Mendes Neto, Miguel Soares Tepedino, Nelson Almeida d’Ávila Melo, Leonardo Balsalobre, Adriano M. Alencar, Renato Stefanini, Rogério Pezato, Claudina Perez-Novo, Ana Bezerra Soter, Claudia Regina Figueiredo, Richard Louis Voegels, Eduardo Kosugi Macoto, Jonatas do Amaral, Pedro Alessandro Leite de Oliveira, Renata Ribeiro de Mendonça Pilan, Luciano Lobato Gregório |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Nasal cavity
nasal mucosa SURFACE sinusitis lcsh:Medicine Mucous membrane of nose Inflammation CHRONIC RHINOSINUSITIS Disease Bioinformatics medicine Genetic predisposition otorhinolaryngologic diseases Medicine and Health Sciences Nasal polyps Sinusitis Pathological Update Manuscript nasal polyps business.industry lcsh:R lcsh:Otorhinolaryngology medicine.disease lcsh:RF1-547 medicine.anatomical_structure Otorhinolaryngology airway inflammation CELLS Human medicine medicine.symptom business |
| Zdroj: | INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY International Archives of Otorhinolaryngology, Vol 23, Iss 02, Pp 241-249 (2019) International Archives of Otorhinolaryngology, Volume: 23, Issue: 2, Pages: 241-249, Published: 18 JUL 2019 International Archives of Otorhinolaryngology |
| ISSN: | 1809-9777 1809-4864 |
| Popis: | Introduction The importance of our study lies in the fact that we have demonstrated the occurrence of mechanical dysfunction within polypoid tissues, which promotes the development of polyps in the nasal cavity. Objective To change the paradigm of nasal polyposis (NP). In this new conception, the chronic nasal inflammatory process that occurs in response to allergies, to pollution, to changes in the epithelial barrier, or to other factors is merely the trigger of the development of the disease in individuals with a genetic predisposition to an abnormal tissue remodeling process, which leads to a derangement of the mechanical properties of the nasal mucosa and, consequently, allows it to grow unchecked. Data Synthesis We propose a fundamentally new approach to intervening in the pathological process of NP, addressing biomechanical properties, fluid dynamics, and the concept of surface tension. Conclusion The incorporation of biomechanical knowledge into our understanding of NP provides a new perspective to help elucidate the physiology and the pathology of nasal polyps, and new avenues for the treatment and cure of NP. |
| Databáze: | OpenAIRE |
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