Incidence of fractures in patients with multiple sclerosis: the Danish National Health Registers

Autor: Marloes T Bazelier, Nils Koch-Henriksen, Joan Bentzen, Frank de Vries, Hubert G. M. Leufkens, Tjeerd-Pieter van Staa, Peter Vestergaard
Rok vydání: 2011
Předmět:
Male
Pediatrics
Time Factors
Denmark
Osteoporosis
Tibia Fracture
Fractures
Bone
Risk Factors
80 and over
Odds Ratio
Registries
Aged
80 and over
Hip fracture
education.field_of_study
Incidence
Incidence (epidemiology)
Age Factors
Middle Aged
Osteoporosis/epidemiology
Neurology
Female
Femoral Fractures
Adult
medicine.medical_specialty
Bone/epidemiology
Hip Fractures/epidemiology
Multiple Sclerosis
Adolescent
Population
Risk Assessment
Young Adult
Age Distribution
Sex Factors
Multiple Sclerosis/epidemiology
medicine
Humans
Femur
Tibia
Sex Distribution
education
Aged
Femur fracture
Hip Fractures
business.industry
Tibial Fractures/epidemiology
medicine.disease
Denmark/epidemiology
Surgery
Femoral Fractures/epidemiology
Tibial Fractures
Case-Control Studies
Fractures
Bone/epidemiology
Neurology (clinical)
business
Fractures
Zdroj: Multiple Sclerosis Journal, 18(5), 622-7. SAGE Publications Ltd
Bazelier, M T, de Vries, F, Bentzen, J, Vestergaard, P, Leufkens, H G, van Staa, T-P & Koch-Henriksen, N 2012, ' Incidence of fractures in patients with multiple sclerosis: the Danish National Health Registers ', Multiple Sclerosis, vol. 18, no. 5, pp. 622-7 . https://doi.org/10.1177/1352458511426739
Bazelier, M T, de Vries, F, Bentzen, J, Vestergaard, P, Leufkens, H G M, van Staa, T P & Koch-Henriksen, N 2012, ' Incidence of fractures in patients with multiple sclerosis: the Danish National Health Registers ', Multiple Sclerosis Journal, vol. 18, no. 5, pp. 622-627 . https://doi.org/10.1177/1352458511426739
ISSN: 1477-0970
1352-4585
DOI: 10.1177/1352458511426739
Popis: Background: Patients with multiple sclerosis (MS) are potentially at high risk of fracture due to falls and osteoporosis. Objective: To estimate incidence rates of fractures in MS patients, stratified by fracture type, sex and age, and to compare these rates with controls. Methods: The case population consisted of all patients with an accepted diagnosis of MS in the Danish MS Registry (1949–2007). Data were linked to the National Hospital Discharge Register (1977–2007). Patients with MS ( n = 11,157) were 1:6 matched by year of birth, gender, calendar time and region to persons without MS (controls). Incidence rates of fracture were estimated as the number of fractures per 1000 person-years. Incidence rate ratios (IRRs) were calculated by dividing fracture rates in MS patients by fracture rates in controls. Results: Among patients with MS, the incidence rate of any fracture yielded 22.8 per 1000 person-years. The IRR of any fracture between MS patients and controls was 1.40 (95% CI 1.33–1.46). In particular, IRRs of tibia fracture (3.36 [2.75–4.11]), femur fracture (6.66 [5.06–8.76]) and hip fracture (3.20 [2.83–3.62]) were elevated in MS patients versus controls. Conclusion: Fractures occurred more often in patients with MS, especially fractures of the tibia, hip and femur.
Databáze: OpenAIRE
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