Pancreatic stellate cell: physiologic role, role in fibrosis and cancer
| Autor: | Minote Apte, Jeremy S. Wilson, Romano C. Pirola |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Cell signaling
Pathology medicine.medical_specialty Pancreatic stellate cell Cell Communication Fibrosis Pancreatitis Chronic medicine Humans Pancreatitis chronic Pancreas business.industry Pancreatic Stellate Cells Gastroenterology Cancer medicine.disease Actins Pancreatic Neoplasms medicine.anatomical_structure Gene Expression Regulation Hepatic stellate cell Disease Progression Pancreatitis business Signal Transduction |
| Zdroj: | Current opinion in gastroenterology. 31(5) |
| ISSN: | 1531-7056 |
| Popis: | Ever since the first descriptions of methods to isolate pancreatic stellate cells (PSCs) from rodent and human pancreas 17 years ago, rapid advances have been made in our understanding of the biology of these cells and their functions in health and disease. This review updates recent literature in the field, which indicates an increasingly complex role for the cells in normal pancreas, pancreatitis and pancreatic cancer.Work reported over the past 12 months includes improved methods of PSC immortalization, a role for PSCs in islet fibrosis, novel factors causing PSC activation as well as those inducing quiescence, and translational research aimed at inhibiting the facilitatory effects of PSCs on disease progression in chronic pancreatitis as well as pancreatic cancer.Improved understanding of the role of PSCs in pancreatic pathophysiology has prompted a focus on translational studies aimed at developing novel approaches to modulate PSC function in a bid to improve clinical outcomes of two major fibrotic diseases of the pancreas: chronic pancreatitis and pancreatic cancer. |
| Databáze: | OpenAIRE |
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