Delayed Sodium Channel Inactivation Mimics Long QT Syndrome 3
| Autor: | Christian Mewis, Ludger Seipel, Volker Kühlkamp, Ralph F. Bosch |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Cardiotonic Agents Ventricular Tachyarrhythmias Long QT syndrome Torsades de pointes QT interval Piperazines Sodium Channels Electrocardiography Internal medicine medicine Humans Single-Blind Method Infusions Intravenous Pharmacology Acquired long QT syndrome business.industry Sodium channel medicine.disease Electrophysiology Long QT syndrome type 3 Long QT Syndrome Anesthesia Tachycardia Ventricular Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Cardiovascular Pharmacology. 42:113-117 |
| ISSN: | 0160-2446 |
| Popis: | DPI 201-106 delays sodium channel inactivation. Acute administration of DPI 201-106 prolonged the QT interval, provoked spontaneous torsades de pointes in one patient, and facilitated stimulation-induced polymorphic ventricular tachyarrhythmias in two patients. Similar to the observations in animal studies, delaying sodium channel inactivation is a new form of the acquired long QT syndrome, mimicking long QT syndrome type 3. |
| Databáze: | OpenAIRE |
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