Cord blood Insulin-like peptide 3 (INSL3) but not testosterone is reduced in idiopathic cryptorchidism

Autor: Patricia Panaïa-Ferrari, Françoise Brucker-Davis, Kathy Wagner-Mahler, Patrick Fénichel, Patrick Coquillard, Najiba Lahlou
Přispěvatelé: Centre Hospitalier Universitaire de Nice (CHU Nice), Centre Méditerranéen de Médecine Moléculaire (C3M), Université de Nice Sophia-Antipolis (UNSA), AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Sophia Agrobiotech (ISA), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Recherche Agronomique (INRA), Clinical Research Board of Nice University Hospital, French Research Ministry, Institut de Recherche Endocrinienne et Metabolique, Hopital Cochin, Paris
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Clinical Endocrinology
Clinical Endocrinology, Wiley, 2015, 82 (2), pp.242-247. ⟨10.1111/cen.12500⟩
ISSN: 0300-0664
1365-2265
Popis: SummaryBackground Cryptorchidism, the most frequent congenital malformation in full-term male newborns, increases the risk of hypofertility and testicular cancer. Most cases remain idiopathic but epidemiological and experimental studies have suggested a role of both genetic and environmental factors. Physiological testicular descent is regulated by two major Leydig hormones: insulin-like peptide 3 (INSL3) and testosterone. Objectives To study the endocrine context at birth as a reflection of late pregnancy in isolated idiopathic cryptorchidism and to analyse the possible disruptions of INSL3 and/or testosterone. Methods From a prospective case–control study at Nice University Hospital, we assessed 180 boys born after 34 weeks gestation: 52 cryptorchid (48 unilateral, 4 bilateral; 26 transient, 26 persistent), and 128 controls matched for term, weight and time of birth. INSL3 and testosterone were measured in cord blood and compared in both groups as were other components of the pituitary-gonadic axis: LH, HCG, FSH, AMH and SHBG. Results INSL3 was decreased in cryptorchid boys (P = 0·031), especially transient cryptorchid (P = 0·029), while testosterone was unchanged as were the other hormones measured. INSL3 was significantly decreased (P = 0·018) in the group of 20 with nonpalpable testes compared with the group of 21 with palpable testes (15 suprascrotal, five inguinal, one high scrotal) according to Scorer classification. In the whole population, INSL3 correlated positively with LH and negatively with AMH, but with no other measured hormones. Conclusions INSL3 but not testosterone is decreased at birth in idiopathic cryptorchidism, especially in transient forms. This hormonal decrease may contribute to the impaired testicular descent along with genetic and anatomical factors. Whether foetal environment (nutritional and/or toxicological) interferes with INSL3 secretion in humans remains to be confirmed.
Databáze: OpenAIRE
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