Adenosine signaling in reserpine-induced depression in rats
| Autor: | Thomas C. Hanff, Thomas R. Minor |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Adenosine Reserpine medicine.drug_class medicine.medical_treatment Intraperitoneal injection Neuropsychological Tests Pharmacology Rats Sprague-Dawley Random Allocation Behavioral Neuroscience Adenosine A1 receptor chemistry.chemical_compound Theophylline Caffeine Flavins Internal medicine Purinergic P1 Receptor Agonists medicine Animals Swimming Depression (differential diagnoses) Depressive Disorder Adrenergic Uptake Inhibitors Dose-Response Relationship Drug Receptors Purinergic P1 Antagonist Brain Receptor antagonist Endocrinology Purinergic P1 Receptor Antagonists chemistry medicine.drug |
| Zdroj: | Behavioural Brain Research. 286:184-191 |
| ISSN: | 0166-4328 |
| Popis: | A single, 6 mg/kg intraperitoneal injection of reserpine increased floating time during forced swim testing 24h after administration in rats in five experiments. Although such behavioral depression traditionally is attributed to drug-induced depletion of brain monoamines, we examined the potential contribution of adenosine signaling, which is plausibly activated by reserpine treatment and contributes to behavioral depression in other paradigms. Whereas peripheral administration of the highly selective A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (0.5, 1.0, or 5.0mg/kg i.p.) 15 min before swim testing failed to improve performance in reserpine-treated rats, swim deficits were completely reversed by 7 mg/kg of the nonselective receptor antagonist caffeine. Performance deficits were also reversed by the nonselective A2 antagonist 3,7-dimethylxanthine (0, 0.5, 1.0mg/kg i.p.), and the highly selective A2A receptor antagonist (CSC: 8-(3 chlorostyral)caffeine) (0.01, 0.1, or 1.0mg/kg i.p.) in a dose-dependent manner. The highly selective A2B antagonist alloxazine had no beneficial effect on swim performance at any dose under study (0.1, 1.0, and 5.0mg/kg i.p.). |
| Databáze: | OpenAIRE |
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