Consistent Fusion of MOZ and TIF2 in AML with inv(8)(p11q13)
| Autor: | Ann E. Watmore, Nicholas C.P. Cross, John M. Goldman, Melina Carapeti, Ricardo C.T. Aguiar |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Cancer Research
Molecular Sequence Data Chromosome Disorders Biology Leukemia Myelomonocytic Acute Fusion gene Nuclear Receptor Coactivator 2 Acetyltransferases Genetics Humans Molecular Biology Gene Histone Acetyltransferases Southern blot Chromosomal inversion Chromosome Aberrations Fusion Models Genetic Breakpoint breakpoint cluster region Myeloid leukemia biochemical phenomena metabolism and nutrition Blotting Southern Karyotyping Chromosome Inversion Chromosomes Human Pair 8 Transcription Factors |
| Zdroj: | Cancer Genetics and Cytogenetics. 113:70-72 |
| ISSN: | 0165-4608 |
| Popis: | We have recently cloned the inv(8)(p11q13) in a patient with acute myeloid leukemia (AML), and demonstrated a fusion between the MOZ and TIF2 genes at 8p11 and 8q13, respectively. We have partially characterized a further case of AML with the same karyotypic abnormality. Rearrangements were detected by Southern blotting with a TIF2 probe that was close to the breakpoint in the original inv(8) case and with a MOZ probe corresponding to the breakpoint cluster region in the t(8;16) (p11;p13). These findings indicate the existence of breakpoint cluster regions within both genes and demonstrate that the MOZ-TIF2 fusion is consistently associated with the inv(8)(p11q13). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect