Classification of breast tissue using a laboratory system for small-angle x-ray scattering (SAXS)
| Autor: | Greg Falzon, Stewart A. Hart, Jane Fox, Karen Siu, Robert A. Lewis, Sabeena Sidhu |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Materials science
Breast Neoplasms Bragg peak Severity of Illness Index law.invention Optics Nuclear magnetic resonance X-Ray Diffraction law Scattering Small Angle Humans Radiology Nuclear Medicine and imaging Breast Principal Component Analysis Radiological and Ultrasound Technology business.industry Small-angle X-ray scattering Scattering Discriminant Analysis Linear discriminant analysis Synchrotron Intensity (physics) Radiography Amplitude Adipose Tissue Case-Control Studies Microfibrils Principal component analysis Female business Synchrotrons |
| Zdroj: | Physics in Medicine and Biology. 56:6779-6791 |
| ISSN: | 1361-6560 0031-9155 |
| DOI: | 10.1088/0031-9155/56/21/002 |
| Popis: | Structural changes in breast tissue at the nanometre scale have been shown to differentiate between tissue types using synchrotron SAXS techniques. Classification of breast tissues using information acquired from a laboratory SAXS camera source could possibly provide a means of adopting SAXS as a viable diagnostic procedure. Tissue samples were obtained from surgical waste from 66 patients and structural components of the tissues were examined between q = 0.25 and 2.3 nm(-1). Principal component analysis showed that the amplitude of the fifth-order axial Bragg peak, the magnitude of the integrated intensity and the full-width at half-maximum of the fat peak were significantly different between tissue types. A discriminant analysis showed that excellent classification can be achieved; however, only 30% of the tissue samples provided the 16 variables required for classification. This suggests that the presence of disease is represented by a combination of factors, rather than one specific trait. A closer examination of the amorphous scattering intensity showed not only a trend of increased scattering intensity with disease severity, but also a corresponding decrease in the size of the scatterers contributing to this intensity. |
| Databáze: | OpenAIRE |
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