Addressing cancer signal transduction pathways with antisense and siRNA oligonucleotides
| Autor: | Rudolph L Juliano |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
AcademicSubjects/SCI01140 Cell signaling AcademicSubjects/SCI01060 Oligonucleotide AcademicSubjects/SCI00030 Cancer Cancer signaling Context (language use) Computational biology Biology medicine.disease AcademicSubjects/SCI01180 Small molecule 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Ras Signaling Pathway 030220 oncology & carcinogenesis medicine AcademicSubjects/SCI00980 Signal transduction Survey and Summary |
| Zdroj: | Nar Cancer |
| ISSN: | 2632-8674 |
| Popis: | Signal transduction pathways play key roles in the initiation, progression and dissemination of cancer. Thus, signaling molecules are attractive targets for cancer therapeutics and enormous efforts have gone into the development of small molecule inhibitors of these pathways. However, regrettably, there has been only moderate progress to date, primarily in connection with the RAS signaling pathway. Oligonucleotide-based drugs potentially offer several advantages for addressing signaling pathways, including their exquisite selectivity and their ability to exploit both enzymatic and nonenzymatic targets. Nonetheless, there are problems inherent in the oligonucleotide approach, not the least being the challenge of effectively delivering these complex molecules to intracellular sites within tumors. This survey article will provide a selective review of recent studies where oligonucleotides were used to address cancer signaling and will discuss both positive aspects and limitations of those studies. This will be set in the context of an overview of various cancer signaling pathways and small molecule approaches to regulate those pathways. The survey will also evaluate the challenges and opportunities implicit in the oligonucleotide-based approach to cancer signaling and will point out several possibilities for future research. |
| Databáze: | OpenAIRE |
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