Combination chemotherapy for advanced squamous cell carcinoma of the head and neck
| Autor: | J. R. Hebel, Donald D. Coker, John J. Coleman, Paul B. Chretien, Don M. Morris, E. George Elias, Mukund S. Didolkar, William C. Gray, Thavinsakdi Viravathana, Theresa A. Zentai |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Antineoplastic Agents Bleomycin Gastroenterology chemistry.chemical_compound Internal medicine Medicine Preoperative chemotherapy Humans Basal cell Head and neck Survival rate Aged business.industry Head and neck cancer Combination chemotherapy Middle Aged medicine.disease High dose methotrexate Methotrexate Otorhinolaryngology chemistry Head and Neck Neoplasms Carcinoma Squamous Cell Drug Therapy Combination Female Cisplatin business |
| Zdroj: | Headneck surgery. 4(2) |
| ISSN: | 0148-6403 |
| Popis: | Fifty-one patients (32 previously untreated, 19 previously treated) with advanced squamous cell carcinoma of the head and neck received a single course of combination chemotherapy consisting of high dose cis-platinum (DDP), bleomycin (Bleo), +/- high dose methotrexate (MTX). Thirty-three (65%) patients responded to therapy; 5 (10%) of these patients had a complete response. Previously untreated patients and those who received the three drugs (DDP, Bleo and MTX) had the highest response rates. The duration of response was 8 to 12 weeks. Seven (15%) patients showed a two-year survival rate. All nonresponders were dead of disease within two years. Three (56%) of the five complete-response patients and 4 (21%) of the partial-response patients survived for two years. The role of preoperative chemotherapy in head and neck cancer is yet to be conclusively defined. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text