Enantio and diastereoselective total synthesis of all four stereoisomers of germicidin N

Autor:	Tsuyoshi Douchi, Yasumasa Sugiyama, Shinji Tanimori, Masahiro Akitake, Motohiro Sonoda
Rok vydání:	2020
Předmět:	biology 010405 organic chemistry Chemistry Stereochemistry Organic Chemistry Enantioselective synthesis Total synthesis Germicidin 010402 general chemistry biology.organism_classification 01 natural sciences Streptomyces 0104 chemical sciences chemistry.chemical_compound Algae
Zdroj:	Synthetic Communications. 50:1504-1511
ISSN:	1532-2432 0039-7911
Popis:	Germicidin N (3-ethyl-4-hydroxy-6-[(1S, 2 R)−2-hydroxy-1-methylpropyl]-2H-pyran-2-one, 1), a new α-pyrone from the extracts of a Streptomyces sp. derived from marine algae, has been synthesized for the first time as four possible diastereomers from chiral β-hydroxyester ((S)−6 and (R)−9) through the stereoselective alkylation, Claisen condensation followed by cyclization in a straightforward manner.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a58a473c90eaeb1476f9d3e7faa2c153 https://doi.org/10.1080/00397911.2020.1745240 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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