Clustering of organ-specific autoimmunity: a case presentation of multiple sclerosis and connective tissue disorders
| Autor: | Murat Icen, Osman Tanik, Isil Yazici, Jale Agaoglu, Nilufer Kale |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Pathology Multiple Sclerosis Neurology Connective tissue Familial Mediterranean fever Autoimmunity Dermatology Methylprednisolone Scleroderma Autoimmune Diseases Paraparesis Activities of Daily Living medicine Demyelinating disease Cluster Analysis Humans Spondylitis Ankylosing Treatment Failure Connective Tissue Diseases Gait Disorders Neurologic Ankylosing spondylitis business.industry Multiple sclerosis Brain Interferon-beta General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Familial Mediterranean Fever Psychiatry and Mental health medicine.anatomical_structure Rheumatoid arthritis Immunology Disease Progression Neurology (clinical) Mitoxantrone business |
| Zdroj: | Neurological Sciences. 29:471-475 |
| ISSN: | 1590-3478 1590-1874 |
| DOI: | 10.1007/s10072-008-1015-1 |
| Popis: | Multiple sclerosis (MS) is the most common demyelinating disease caused by an autoimmune inflammatory process in the central nervous system (CNS) and is associated with aberrant immune response to myelin selfantigens. Coexistence of MS with other autoimmune disorders, including connective tissue disorders including systemic lupus erythematosus, rheumatoid arthritis, Sjögren's syndrome and scleroderma have been reported previously. In the present article we report the coexistence of MS, familial mediterranean fever and ankylosing spondylitis in a patient and review the clinical presentation, neurologic findings, cerebrospinal fluid and radiologic characteristics and treatment options. We further discuss the immunopathogenetic mechanisms for a possible association between MS and autoimmune disorders. |
| Databáze: | OpenAIRE |
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