Genetic variation in HIF‐2α attenuates ventilatory sensitivity and carotid body growth in chronic hypoxia in high‐altitude deer mice

Autor:	Catherine M. Ivy, Jonathan P. Velotta, Zachary A. Cheviron, Graham R. Scott
Rok vydání:	2022
Předmět:	Carotid Body Peromyscus Physiology Acclimatization Altitude Basic Helix-Loop-Helix Transcription Factors Animals Genetic Variation Hypoxia
Zdroj:	The Journal of Physiology. 600:4207-4225
ISSN:	1469-7793 0022-3751
DOI:	10.1113/jp282798
Popis:	The gene encoding HIF-2α, Epas1, has experienced a history of natural selection in many high-altitude taxa, but the functional role of mutations in this gene is still poorly understood. We investigated the influence of the high-altitude variant of Epas1 in North American deer mice (Peromyscus maniculatus) on the control of breathing and carotid body growth during chronic hypoxia. We created hybrids between high- and low-altitude populations of deer mice to disrupt linkages between genetic loci so that the physiological effects of Epas1 alleles (Epas1
Databáze:	OpenAIRE
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